Background. Sugammadex is a new reversal agent that has entered use recently. It is known that with sugammadex some changes in\ncoagulation parameters occur without documented clinical results.Aimof theWork.The objective of this study was to identify effects\nof sugammadex on liver functions, coagulation, and fibrinolytic systems. Methods. Thirty-six rats were randomized into six groups:\nGroup I, control; Group II, rocuronium group; Group III, sugammadex administered in 16mg kg?1 dose; Group IV, sugammadex\nadministered in 96mg kg?1 dose; Group V, rocuronium and sugammadex administered in 16mg kg?1 dose; and Group VI,\nrocuronium and sugammadex administered in 96mg kg?1 dose. After 120 minutes, blood samples were obtained for prothrombin\ntime, activated partial thromboplastin time, D-dimer, fibrinogen, aspartate aminotransferase, alanine aminotransferase, albumin,\nplatelet, and mean platelet volume analyses. Results. Compared to the control group, in all groups measured parameters did not\nshow any effect froma statistical viewpoint either due to the administered drugs alone or due to interaction effects. Conclusion.The\nconclusion was reached that administration of sugammadex in rats did not have any significant effect on the fibrinolytic system,\ncoagulation parameters, and liver function.
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